Function. This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. This gene is expressed at high levels in a number of fetal epithelia.Aliases: FAT1, CDHF7, CDHR8, FAT, ME5, hFat1, . There’s one gene that’s getting a lot of attention, called FTO. Scientists found that people with certain differences in this gene have a 20% to 30% higher chance of obesity. And those Author: Lisa Hill.
Fat mass and obesity-associated protein also known as alpha-ketoglutarate-dependent dioxygenase FTO is an enzyme that in humans is encoded by the FTO gene located on chromosome 16.As one homolog in the AlkB family proteins, it is the first mRNA demethylase that has been identified. Certain variants of the FTO gene appear to be correlated with obesity in humans.Aliases: FTO, ALKBH9, GDFD, BMIQ14, fat mass and . Aug 19, 2015 · Scientists discover how key gene makes people fat. researchers blocked the faulty gene’s effect in mice and found they became 50 percent leaner than other mice despite eating a Author: Marilynn Marchione.
Nov 13, 2017 · The study, which was conducted in mice, shows that the gene variation causes fat cells to suck up glucose faster than normal, more than doubling their size. When an aging metabolism or high-fat diet is added to the equation, obesity becomes all but inevitable. Aug 12, 2018 · A cadherin gene, FAT, confers susceptibility to bipolar disorder in four independent cohorts. In mice, Fat was shown to be significantly downregulated and Catnb and Enah were significantly upregulated in response to therapeutic doses of lithium. Processing of FAT1 and the translocation of its cytoplasmic domain to the nucleus were studied.